145058-17-9Relevant academic research and scientific papers
An efficient entry to optically active anti- and syn-β-amino-α- trifluoromethyl alcohols
Fustero, Santos,Albert, Laia,Acena, Jose Luis,Sanz-Cervera, Juan F.,Asensio, Amparo
, p. 605 - 608 (2008/09/16)
The reaction of chiral 5,6-dihydro-2H-1,4-oxazin-2-ones with TMSCF 3 in the presence of a suitable activator leads to trifluoromethyl lactols, which can be selectively reduced to anti-β-amino-α- trifluoromethyl alcohols. The corresponding syn d
An Efficient and Practical Synthesis of L-α-Amino Acids Using (R)-Phenylglycinol as a Chiral Auxiliary
Inaba, Takashi,Kozono, Ichiro,Fujita, Makoto,Ogura, Katsuyuki
, p. 2359 - 2365 (2007/10/02)
L-α-Amino acids including L-α-arylglycines were conveniently and stereoselectively synthesized via the α-amino carbonitriles given by the Strecker reaction of (R)-2-amino-2-phenylethanol with aldehydes and hydrogen cyanide.The stereoselectivity of these α-amino carbonitriles was thermodynamically controlled.
