145060-60-2

Upstream product

• 890-38-0 2-deoxyinosine 
• 687983-85-3 1-[9-((2R,4S,5R)-4-Acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-pyridinium 
• 145060-59-9 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(6-thioxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 106568-79-0 9-(3',5'-di-O-acetyl-2'-deoxy-β-D-erythro-pentofuranosyl)-1H-purine-6(9H)-one 
• 2239-64-7 6-mercaptopurine-2’-deoxyribose 
• 70-34-8 2,4-Dinitrofluorobenzene 

Downstream Products

• 145060-62-4 (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(2,4-dinitro-phenylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-ol 

Relevant academic research and scientific papers

Synthesis and duplex stability of oligodeoxynucleotides containing 6-mercaptopurine

simple procedures for conversion of 2′-deoxyinosine into 6-thio-2′-deoxyinosine (III) and for preparation of S-protected 6-mercatopurine phosphoramidite (VI) are described. The monomer (VI) was incorporated into DNA oligomers and converted into oligomers containing 6-mercaptopurine and other purines modified at the 6-position. Measurements of the melting temperature (Tm) of DNA duplexes containing 6-mercaptopurine or 6-thioguanine show that both preferentially pair with cystosine rather than with thymine, but that the presence of the S generally destabilises the DNA duplex.