1450622-60-2

Upstream product

• 1450622-74-8 C₁₈H₂₆ 
• 65413-33-4 (4-tert-butyl-benzyl)-triphenyl-phosphonium bromide 
• 29778-26-5 [(4-tert-butylphenyl)ethynyl]benzene 
• 1450622-47-5 1-(tert-butyl)-4-(2-methoxyethyl)benzene 
• 931-51-1 cyclohexylmagnesiumchloride 

Relevant academic research and scientific papers

Regioselective differentiation of vicinal methylene C-H bonds enabled by silver-catalysed nitrene transfer

Silver-catalyzed nitrene insertion enables the formation of benzosultams in good yield and with regioselectivity complementary to other transition metal nitrene-transfer catalysts. Preferential formation of six-membered benzosultam rings predominates for alkyl-substituted benzenesulphonamide precursors. Ligand-controlled tunability is also achieved for benzenesulphonamides with γ-branched alkyl substituents. Mechanistic probes suggest that the reaction pathway differs depending on whether a α (benzylic) or β (homobenzylic) C-H bond undergoes amidation, as well as the catalyst identity.

Reduction of diphenylacetylene using Al powder in the presence of noble metal catalysts in water

Diphenylacetylenes can be reduced to the corresponding diphenylethanes (2) in water in excellent yield using Al powder and Pd/C at 60?°C for 3?h in a sealed tube. In addition, the complete reduction of both aromatic rings required 80?°C for 15?h with Al powder in the presence of Pt/C. However, the nature of hydrogenated product formed was found to be strongly influenced by the reaction temperature, time, volume of water and the amount of catalyst being employed.

Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C-O bond cleavage

The first iron-catalyzed formal cross coupling of homobenzylic methyl ethers with alkyl Grignard reagents is realized. The reaction is proposed to proceed through a sequence of dehydroalkoxylation to form the vinyl-intermediate, followed by Fe-catalyzed selective carbometalation to form a benzylic Grignard reagent.