1450644-28-6

Basic information

• Product Name: TNU9056
• Synonyms: TNU9056;TNU9056 1,2-Di(isothiazol-5-yl)disulfane;5-(1,2-thiazol-5-yldisulfanyl)-1,2-thiazole
• CAS NO: 1450644-28-6
• Molecular Formula: C6H4N2S4
• Molecular Weight: 232.36936
• Mol File: 1450644-28-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 209.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.60±0.1 g/cm3(Predicted)
• PKA: 2.44±0.38(Predicted)
• CAS DataBase Reference: TNU9056(CAS DataBase Reference)
• NIST Chemistry Reference: TNU9056(1450644-28-6)
• EPA Substance Registry System: TNU9056(1450644-28-6)

Safety Data

• Hazardous Substances Data: 1450644-28-6(Hazardous Substances Data)

Usage

Description

TNU9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor that plays a significant role in regulating protein acetylation in prostate cancer cell lines. It is known for its ability to block DNA damage response, thereby decreasing the proliferation of LNCaP cells and inducing apoptosis through caspase activation.

Uses

Used in Pharmaceutical Industry:
TNU9056 is used as an anticancer agent for the treatment of prostate cancer. It works by inhibiting protein acetylation in prostate cancer cell lines, blocking DNA damage response, and inducing apoptosis in LNCaP cells through caspase activation.
Used in Cancer Research:
TNU9056 is used as a research tool for studying the role of KAT5 (Tip60) histone acetyltransferase in the development and progression of prostate cancer. It helps researchers understand the underlying mechanisms of cancer cell proliferation and apoptosis, which can lead to the development of novel therapeutic strategies.
Used in Drug Development:
TNU9056 is used as a lead compound in the development of new drugs targeting KAT5 (Tip60) histone acetyltransferase. Its selective inhibition of this enzyme makes it a promising candidate for the development of targeted therapies for prostate cancer and potentially other cancer types.