1450655-76-1 Usage
Uses
CPI-169 is a heteroaryl amide that was discovered useful as modulator of Me modifying enzymes.
Biological Activity
cpi-169 is a novel, small molecule and potent inhibitor of enhancer of zeste homolog 2 (ezh2) with an ic50 value of <1nm for polycomb repressive complex 2 (prc2) [1].cpi-169 has been found to be a potent ezh2 inhibitor with an ic50 value of <1nm for polycomb repressive complex 2 (prc2). in addition, cpi-169 has been reported to reduce cellular levels of histone h3 on lysine 27(h3k27) with an ec50 value of 70nm. moreover, cpi-169 has been exhibited to trigger cell cycle arrest and apoptosis in cells. apart from these, treatment the inhibitor at 200mpk twice daily, cpi-169 has been noted to have a well tolerated in mice with no observed toxic effect or body weight loss [1].
references
[1] vidya balasubramanian, priya iyer, shilpi arora, patrick troyer, emmanuel normant. constellation pharmaceuticals, cambridge, ma. cpi-169, a novel and potent ezh2 inhibitor, synergizes with chop in vivo and achieves complete regression in lymphoma xenograft models
Check Digit Verification of cas no
The CAS Registry Mumber 1450655-76-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,0,6,5 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1450655-76:
(9*1)+(8*4)+(7*5)+(6*0)+(5*6)+(4*5)+(3*5)+(2*7)+(1*6)=161
161 % 10 = 1
So 1450655-76-1 is a valid CAS Registry Number.
1450655-76-1Relevant articles and documents
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
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Paragraph 0086; 0087, (2014/08/20)
Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.
