145070-47-9Relevant academic research and scientific papers
Halichoblelide, a potent cytotoxic macrolide from a Streptomyces species separated from a marine fish
Yamada, Takeshi,Minoura, Katsuhiko,Numata, Atsushi
, p. 1721 - 1724 (2002)
Halichoblelide, a novel macrolide with potent cytotoxicity against tumour cells in culture, has been isolated from a strain of Streptomyces hygroscopicus originally separated from the marine fish Halichoeres bleekeri, and the absolute stereostructure has been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and some chemical transformations.
Stereochemical studies on esperamicins: The absolute configuration of their bicyclic aglycone
Golik, Jerzy,Krishnan, Bala,Doyle, Terrence W.,VanDuyne, Gregory,Clardy, Jon
, p. 6049 - 6052 (1992)
Single crystal x-ray diffraction analyses revealed the relative configuration of esperamicin X and the absolute configuration of 2-deoxy fucose, a fragment present in all known esperamicins. Comparison of the CD curves for esperamicins X and Z gave evidence for their identical chirality. Based on these data the absolute stereochemistry of [7,3,1] bicyclic aglycone of esperamicins has been assigned as C-1 (S), C-8 (S). and C-12 (S).
Halichoblelides B and C, potent cytotoxic macrolides from a Streptomyces species separated from a marine fish
Yamada, Takeshi,Kikuchi, Takashi,Tanaka, Reiko,Numata, Atsushi
, p. 2842 - 2846 (2012/07/28)
Halichoblelide B (1) and C (2), novel macrolides with potent cytotoxicity against tumor cells in culture, have been isolated from a strain of Streptomyces hygroscopicus originally derived from the marine fish Halichoeres bleekeri, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and chemical transformations. These compounds exhibited significant cytotoxicity against human cancer cell lines.
