145071-13-2Relevant academic research and scientific papers
Highly lk-Selective Asymmetric Nitrile Oxide Cycloadditions to a C2-Symmetric 1,3-Diacryloyl-2,2-dimethylimidazolidine and 4-Chiral 3-Acryloyl-2,2-dialkyloxazolidines
Kanemasa, Shuji,Onimura, Kenjiro
, p. 8645 - 8658 (2007/10/02)
1,3-Dipolar cycloadditions of benzonitrile oxide to the acrylamides derived from a C2-symmetric 2,2-dimethylimidazolidine and 4-chiral 2,2-dialkyloxazolidines show high lk-diasteroselectivities.Easy separation of the major lk-isomers from the minor ul-diastereomers is followed by reductive removal of the chiral auxiliaries to produce optically pure 2-isoxazoline-5-methanols.Absolute diastereoselectivities were recorded in the nitrile oxide cycloadditions of 3-acryloyl-2,2-dialkyl-4-(diphenylmethyl)oxazolidines at 0 deg C.
