1450729-38-0Relevant articles and documents
A novel highly site-selective synthesis of 2,4,7-triarylpyrrolo[2,3-d] pyrimidines by a combination of palladium(0)-, nickel(0)-, and copper(I)-catalyzed cross-coupling reactions
Urbonas, Rytis V.,Poskus, Vilius,Bucevicius, Jonas,Dodonova, Jelena,Tumkevicius, Sigitas
, p. 1383 - 1386 (2013/07/26)
An efficient highly site-selective synthesis of 2,4,7-triarylpyrrolo[2,3-d] pyrimidines from 4-chloro-2-methylthiopyrrolo[2,3-d]pyrimidine has been developed. The proposed synthetic pathway is based on three sequential arylation reactions: Suzuki coupling at position 4 of pyrrolo[2,3-d]pyrimidine, copper(I)-catalyzed N(7)-arylation and nickel(0)-catalyzed desulfitative reaction of 2-methylthio group with aryl Grignard reagents. Georg Thieme Verlag Stuttgart · New York.