1450754-38-7 Usage
Uses
Used in Chemical Probe Synthesis:
3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is used as a chemical probe for the synthesis of ligands or pharmacophores. Its application reason is that when appended to a ligand or pharmacophore through its iodinated linker, it allows for UV light-induced covalent modification of a biological target.
Used in Biological Target Modification:
3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is used as a modifier for biological targets. The application reason is the potential for downstream applications via the alkyne tag, which enables further interactions and modifications.
Used in Chemical Biology Experiments:
3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is used as a multi-functional building block in chemical biology experiments. It can be used alone or in parallel with other multi-functional building blocks to discover the optimal probe for specific applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is used as a key component in the development of new drugs and drug delivery systems. Its application reason is the ability to modify biological targets and facilitate the discovery of novel therapeutic agents.
Used in Research and Development:
3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is used as a research tool for exploring the mechanisms of various biological processes and identifying potential therapeutic targets. The application reason is its versatility in chemical probe synthesis and its potential to enhance the understanding of complex biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1450754-38-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,0,7,5 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1450754-38:
(9*1)+(8*4)+(7*5)+(6*0)+(5*7)+(4*5)+(3*4)+(2*3)+(1*8)=157
157 % 10 = 7
So 1450754-38-7 is a valid CAS Registry Number.
1450754-38-7Relevant academic research and scientific papers
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
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, (2019/02/13)
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured.The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, can be used in the treatment of metabolic disorders (e.g. Type 2 diabetes, atherosclerosis, obesity or gout), a disease of the central nervous system (e.g. Alzheimer's disease, multiple sclerosis, Amyotrophic Lateral Sclerosis or Parkinson's disease), lung disease (e.g. asthma, COPD or pulmonary idiopathic fibrosis), liver disease (e.g. NASH syndrome, viral hepatitis or cirrhosis), pancreatic disease (e.g. acute pancreatitis or chronic pancreatitis), kidney disease (e.g. acute kidney injury or chronic kidney injury), intestinal disease (e.g. Crohn's disease or Ulcerative Colitis), skin disease (e.g. psoriasis), musculoskeletal disease (e.g. scleroderma), a vessel disorder (e.g. giant cell arteritis), a disorder of the bones (e.g. osteoarthritis, osteoporosis or osteopetrosis disorders), eye disease (e.g. glaucoma or macular degeneration), a disease caused by viral infection (e.g. HIV or AIDS), an autoimmune disease (e.g. Rheumatoid Arthritis, Systemic Lupus Erythematosus or Autoimmune Thyroiditis), cancer or aging.
