1450806-25-3Relevant articles and documents
Homologative trifluoromethylation of acetals
Hamilton, James Y.,Morandi, Bill,Carreira, Erick M.
, p. 1857 - 1862 (2013/07/26)
Trifluoroethyl α-insertion of acetals has been developed. Aromatic, heteroaromatic, and alkenyl acetals react with in situ generated (trifluoromethyl)diazomethane in the presence of antimony(V) chloride to furnish α-trifluoromethyl acetals. A stereoselective version of this transformation exploiting the acetal as a chiral auxiliary is also presented. Georg Thieme Verlag Stuttgart · New York.