1450817-22-7Relevant articles and documents
Combination of enzyme- and Lewis acid-catalyzed reactions: A new method for the synthesis of 6,7-dihydrobenzofuran-4(5H)-ones starting from 2,5-dimethylfuran and 1,3-cyclohexanediones
Asta, Chimène,Schmidt, Dietmar,Conrad, Jürgen,Frey, Wolfgang,Beifuss, Uwe
, p. 5692 - 5701 (2013/09/12)
The Lewis acid-catalyzed domino 1,2-addition/1,4-addition/elimination between (Z)-3-hexene-2,5-dione and 1,3-dicarbonyls delivers 3-methyl-6,7- dihydrobenzofuran-4(5H)-ones exclusively with yields up to 82%. The combination of this new process with the laccase-catalyzed formation of (Z)-3-hexene-2,5- dione by oxidative cleavage of 2,5-dimethylfuran allows for the synthesis of 6,7-dihydrobenzofuran-4(5H)-ones starting directly from 2,5-dimethylfuran.