1450820-58-2Relevant academic research and scientific papers
Atroposelective [2+2+2] cycloadditions catalyzed by a rhodium(i)-chiral phosphate system
Auge, Mylene,Barbazanges, Marion,Tran, Anh Tuan,Simonneau, Antoine,Elley, Paulin,Amouri, Hani,Aubert, Corinne,Fensterbank, Louis,Gandon, Vincent,Malacria, Max,Moussa, Jamal,Ollivier, Cyril
supporting information, p. 7833 - 7835 (2013/09/02)
Enantioselective cationic Rh(i)-catalyzed [2+2+2] cycloaddition reactions between diynes and isocyanates relying on the chiral anion strategy have been devised. In the presence of [Rh(cod)Cl]2, 1,4-bis(diphenylphosphino) butane, and the silver phosphate salt Ag(S)-TRIP as the unique source of chirality, axially chiral pyridones were isolated with ees up to 82%. This approach is novel in the field of chiral anion-mediated asymmetric catalysis since atroposelective transformations have so far remained unprecedented. It also proves to be complementary to the classical strategy based on chiral L-type ligands.
