1450842-79-1Relevant articles and documents
Formation of highly substituted tetrahydropyranones: Application to the total synthesis of cyanolide A
Tay, Gidget C.,Gesinski, Michael R.,Rychnovsky, Scott D.
, p. 4536 - 4539 (2013/09/24)
A new tetrahydropyranone synthesis has been developed that leads to cis-2,6-disubstituted 3,3-dimethyltetrahydropyran-4-one rings by condensation of an aldehyde and a hydroxy silyl enol ether. The reaction works with a variety of aldehydes to produce the tetrahydropyranone products in moderate to high yields. This new method was applied to the enantioselective synthesis of cyanolide A and its aglycone.