1450893-68-1Relevant academic research and scientific papers
Novel isocyanide-based three-component reaction: A facile synthesis of substituted 1H-chromeno[2,3-d]pyrimidine-5-carboxamides
Soleimani, Ebrahim,Ghorbani, Somayeh,Ghasempour, Hamid Reza
, p. 8511 - 8515 (2013)
A mild and efficient method for the synthesis of 1H-chromeno[2,3-d] pyrimidine-5-carboxamide derivatives via a one-pot, three-component reaction of an isocyanide, barbituric acid, and a salicylaldehyde in the presence of acetic acid in ethanol/water mixture at 75 C is reported. This high atom economy reaction led to the construction of one benzopyran ring, and one amide group in a single synthetic step.
