1450897-67-2Relevant academic research and scientific papers
Dehydrative Cross-Coupling of Allylic Alcohols with Alkynes
Xie, Peizhong,Sun, Zuolian,Li, Shuangshuang,Zhang, Lei,Cai, Xinying,Fu, Weishan,Yang, Xiaobo,Liu, Yanan,Wo, Xiangyang,Loh, Teck-Peng
supporting information, p. 1599 - 1604 (2020/02/13)
A highly efficient Pd/Ca catalytic system for the directly dehydrative cross-coupling of allylic alcohols with terminal alkynes was developed. This calcium salt cocatalyst facilitates the oxidative addition of the palladium catalyst (1 mol %) to the C-OH bond. Then, the in situ-generated hydroxide ion deprotonates the terminal alkynes to promote the formation of the allylalkynylpalladium intermediate, liberating water as the only byproduct. This proposed mechanism is also supported by density functional theory calculations. An anticancer agent was prepared from inexpensive starting materials on a 10 g scale.
Palladium-Catalyzed Alkynylation of Morita-Baylis-Hillman Carbonates with (Triisopropylsilyl)acetylene on Water
Li, Yangxiong,Liu, Li,Kong, Delong,Wang, Dong,Feng, Weichun,Yue, Tao,Li, Chaojun
, p. 6283 - 6290 (2015/06/30)
Direct alkynylation of Morita-Baylis-Hillman carbonates with (triisopropylsilyl)acetylene catalyzed by a Pd(OAc)2-NHC complex was developed "on water" to give the corresponding 1,4-enynes. The significant effects of water amount in the solvent
A Pd(0)-catalyzed direct dehydrative coupling of terminal alkynes with allylic alcohols to access 1,4-enynes
Li, Yang-Xiong,Xuan, Qing-Qing,Liu, Li,Wang, Dong,Chen, Yong-Jun,Li, Chao-Jun
supporting information, p. 12536 - 12539 (2013/09/23)
A direct dehydrative coupling of terminal alkynes with allylic alcohols catalyzed by Pd(PPh3)4 with an N,P-ligand assisted by Ti(OiPr)4 has been developed. The coupling reaction tolerates various functional groups, providing a valuable synthetic tool to access 1,4-enynes.
