145090-28-4Relevant articles and documents
G protein coupled receptor agonist and application thereof in treatment of diabetes
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Paragraph 0016, (2018/06/16)
The invention discloses a structure of a compound. The structural formula of the compound is shown in the description. Found by activity determination, the structure has the effect of a G protein coupled receptor 119 agonist; the G protein coupled receptor 119 agonist has the functions of not causing hypoglycemia of patients and promoting GLP-1 secretion. The compound disclosed by the invention can be further researched and developed as a diabetes-resisting drug. Besides, the invention further discloses a synthesis route and a synthesis method for the compound.
A reversible cysteines protease aminonitrile effective as a new
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Page/Page column 91-92, (2008/06/13)
Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases and pathological co