145092-73-5

Upstream product

• 931-64-6 norbornene 
• 135024-76-9 Acetic acid (2S,3S)-3-hydroxy-bicyclo[2.2.2]oct-2-yl ester 
• 75004-18-1 Acetic acid (2S,3S)-3-acetoxy-bicyclo[2.2.2]oct-2-yl ester 
• 75004-18-1 (2R*,3R*)-2,3-diacetoxybicyclo<2.2.2>octane 
• 103-71-9 phenyl isocyanate 
• 145166-76-3 (2S,3S)-(-)-bicyclo<2.2.2>octane-2,3-diol 

Relevant academic research and scientific papers

Resolution of the Diols of Bicycloheptane, Bicyclooctane and Bicyclooctane by Enzymic Hydrolysis, and their Absolute Configurations

Enzyme (pig liver esterase and lipase from Aspergillus niger)-catalysed enantioselective hydrolyses of racemic diacetates, (1R*,2S*,4R*,5S*)-, and (1R*,2R*,4R*,5R*)-2,5-diacetoxybicycloheptanes, (1R*,2S*,4R*,5S*)-, (1R*,2R*,4R*,5R*)- and (1R*,2R*,4R*,5S*)-2,5-diacetoxybicyclooctanes, (2R*,3R*)-2,3-diacetoxybicyclooctane and (1R*,2S*,6S*,8R*)- and (1R*,2S*,6S*,8S*)-2,8-diacetoxybicyclooctanes gave the corresponding monoacetates and the recovered diacetates in an optically active form.The absolute configurations of the products wereunequivocally determined by chemical correlation to the corresponding known monoacetates, (2S)-(+)-2-acetoxybicycloheptane, (2S)-(+)-2-acetoxybicyclooctane and (2S)-(+)-2-acetoxybicyclooctane, and circular dichroism spectra of keto acetates and diketones derived from the hydrolysis products were examined.