1450992-57-0

Basic information

• Product Name: 2-(o-tolyl)-7H-thieno[2',3':4,5]benzo[1,2,3-ij][2,7]naphthyridin-7-one
• Synonyms: 2-(o-tolyl)-7H-thieno[2',3':4,5]benzo[1,2,3-ij][2,7]naphthyridin-7-one
• CAS NO: 1450992-57-0
• Molecular Weight: 328.394
• Mol File: 1450992-57-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(o-tolyl)-7H-thieno[2',3':4,5]benzo[1,2,3-ij][2,7]naphthyridin-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(o-tolyl)-7H-thieno[2',3':4,5]benzo[1,2,3-ij][2,7]naphthyridin-7-one(1450992-57-0)
• EPA Substance Registry System: 2-(o-tolyl)-7H-thieno[2',3':4,5]benzo[1,2,3-ij][2,7]naphthyridin-7-one(1450992-57-0)

Safety Data

• Hazardous Substances Data: 1450992-57-0(Hazardous Substances Data)

Upstream product

• 34576-98-2 5-bromobenzo[b]thiophene-4-ol 
• 63693-34-5 5-bromo-benzo[b]thiophene-4,7-dione 
• 1450992-69-4 8-methylthieno[2,3-g]quinoline-4,9-diketone 
• 529-20-4 2-methylphenyl aldehyde 

Relevant articles and documents

Scaffold hopping of sampangine: Discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans

Discovery of novel antifungal agents against Aspergillus fumigatus and Cryptococcus neoformans remains a significant challenge in current antifungal therapy. Herein the antifungal natural product sampangine was used as the lead compound for novel antifungal drug discovery. A series of D-ring scaffold hopping derivatives were designed and synthesized to improve antifungal activity and water solubility. Among them, the thiophene derivative S2 showed broad-spectrum antifungal activity, particularly for Aspergillus fumigatus and Cryptococcus neoformans. Moreover, compound S2 also revealed better water solubility than sampangine, which represents a promising antifungal lead compound for further structural optimization.