1450999-65-1Relevant articles and documents
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids
Frolova, Liliya V.,Magedov, Igor V.,Romero, Anntherese E.,Karki, Menuka,Otero, Isaiah,Hayden, Kathryn,Evdokimov, Nikolai M.,Banuls, Laetitia Moreno Y.,Rastogi, Shiva K.,Smith, W. Ross,Lu, Shi-Long,Kiss, Robert,Shuster, Charles B.,Hamel, Ernest,Betancourt, Tania,Rogelj, Snezna,Kornienko, Alexander
, p. 6886 - 6900 (2013/10/01)
We developed synthetic chemistry to access the marine alkaloid rigidins and over 40 synthetic analogues based on the 7-deazaxanthine, 7-deazaadenine, 7-deazapurine, and 7-deazahypoxanthine skeletons. Analogues based on the 7-deazahypoxanthine skeleton exh