145100-12-5

Upstream product

• 145100-02-3 1-carbomethoxy-3-iodo-4,5,6,7-tetrahydro-2H-isoindole 
• 145100-06-7 2(R)-methyl-3(R)-(1'(S)-(benzyloxy)ethyl)-4-pentynoic acid amide 
• 60652-00-8 methyl 4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate 
• 2562-37-0 1-nitrocyclohexene 
• 145071-98-3 (2R,3R)-3-((S)-1-Benzyloxy-ethyl)-2-methyl-pent-4-ynoic acid 

Downstream Products

• 145072-13-5 3-[(3R,4R)-3-((S)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-pyrrolidin-(2Z)-ylidenemethyl]-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Dihydropyrromethenones by Pd(0)-Mediated Coupling of Iodopyrroles and Acetylenic Amides. Synthesis of the A,B-Ring Segment of Phytochrome

Dihydropyrromethenone derivative 32b, which constitutes the A,B-ring segment of phytochrome (6), has been prepared in enantiomerically pure form beginning with acetylenic amide 47b and iodopyrrole 27. The key steps involved the TBAF-catalyzed 5-exo-dig cyclization of the acetylenic pyrrole 48b, followed by thia-Mitsunobu inversion of the resulting alcohol derivative 31b.

Tetrapyrroles. IV. A highly efficient synthesis of homochiral dihydropyrromethenones via Pd○ mediated coupling of iodopyrroles and acetylenic amides

Homochiral dihydropyrromethenones of type 20 have been synthesized in a highly efficient manner by Pd○ mediated coupling of iodopyrrole 14 with acetylenic amides 18, followed by F- catalyzed 5-exo-dig cyclization. In analogous fashion, phytochr