145103-22-6

Upstream product

• 30044-72-5 1,2-dihydro-2-(4-methylbenzoyl)isoquinoline-1-carbonitrile 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 119-65-3 isoquinoline 
• 145103-18-0 2-[[2-benzoyl-1-cyano-1,2-dihydroisoquinolin-1-yl]methyl]benzoic acid methyl ester 

Relevant academic research and scientific papers

Protoberberines from Reissert-Compounds VIII [1]. Oxazoloisoquinolines, New and Efficient Educts for the Synthesis of 8-Oxoprotoberberines

Certain benzylated oxazoloisoquinolinones readily available from Reissert compounds provided an efficient access to 8-oxoprotoberberines in three steps. A series of these new precursors as well as several oxoprotoberberines were prepared and the scope and limitation of this procedure were investigated.

Synthesis of Dibenzoquinolizines - A New Entry to Protoberberines

A novel synthesis to prepare dibenzo-8-quinolizinones 8 is reported using the intramolecular cyclisation of the benzylated Reissert compounds 6 for the key step.Methylation of 8 by methyllithium gives partial deoxygenated coralynes 10 which in turn can be reduced by NaBH4 yielding the 8-methyltetrahydro-protoberberines 11.The structures are assigned by NMR-spectroscopy. Keywords.Reissert compounds; Intramolecular cyclisation; Dibenzo-8-quinolizinones; Deoxygenated coralynes; 8-Methyltetrahydro-protoberberines.