1451044-82-8Relevant academic research and scientific papers
Alkyne hydroacylation: Switching regioselectivity by tandem ruthenium catalysis
Chen, Qing-An,Cruz, Faben A.,Dong, Vy M.
, p. 3157 - 3160 (2015)
By using tandem Ru-catalysis, internal alkynes can be coupled with aldehydes for the synthesis of β,γ-unsaturated ketones. The catalyst promotes alkyne transformations with high regioselectivity, with examples that include the differentiation of a methyl vs ethyl substituent on the alkyne. Mechanistic studies suggest that the regioselectivity results from a selective allene formation that is governed by allylic strain.
A convenient synthesis of α-substituted β,γ-unsaturated ketones and esters via the direct addition of substituted allylic zinc reagents prepared by direct insertion
Saemann, Christoph,Knochel, Paul
, p. 1870 - 1876 (2013/07/26)
A practical and convenient procedure for the synthesis of α-substituted β,γ-unsaturated ketones and esters has been developed. Substituted allylic zinc reagents, prepared via direct metal insertion in substituted allylic halides, react readily with a broad range of acid chlorides and chloroformates furnishing the corresponding α-substituted β,γ-unsaturated ketones and esters in high yield and perfect regioselectivity. Georg Thieme Verlag Stuttgart · New York.
