1451066-66-2Relevant academic research and scientific papers
Synthesis, characterization, and crystal structures of aryl-substituted ferrocenylpyrimidines by site-selective stepwise couplings of 2,4,6-trichloropyrimidine
Xu, Chen,Li, Hongmei,Wang, Zhiqiang,Lou, Xinhua,Fu, Weijun
, p. 767 - 773 (2014/05/20)
A new ferrocenylpyrimidine containing chlorine was conveniently prepared via the coupling reaction of chloromercuriferrocene and 2,4,6- trichloropyrimidine, and a monoaryl-substituted ferrocenyl-pyrimidine was also readily obtained from the Suzuki coupling of the former with phenylboronic acid. The following Suzuki coupling of the monoaryl-substituted derivative with arylboronic acids in the presence of Pd(OAc)2/P(Cy) 3·HBF4 gave diaryl-substituted ferrocenylpyrimidines. These compounds were characterized by elemental analysis, IR, MS, 1H and 13C NMR. Additionally, the structures of the three compounds were determined by single-crystal X-ray analysis. Graphical abstract: [Figure not available: see fulltext.]
