1451070-41-9Relevant academic research and scientific papers
Synthesis and antimicrobial activity of some new thieno[2,3-b]thiophene derivatives
Mabkhot, Yahia Nasser,Kheder, Nabila Abdelshafy,Farag, Ahmad M.
, p. 4669 - 4678 (2013/06/05)
A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a-c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5- diyl)bis(3-acetyl-1-(4- chlorophenyl)-1H-pyrazole-4-carbonitrile) (5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin B against Syncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G against Staphylococcus aureus. Moreover, it was more potent than the standard drug streptomycin against Pseudomonas aeruginosa and Escherichia coli.
