1451070-71-5

Upstream product

• 101906-39-2 Methyl (3R,4R,5R)-3,5-Bis<(tert-butyl)dimethylsilyloxy>-4-hydroxycyclohex-1-ene-1-carboxylate 
• 1451070-67-9 (20S)-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne 
• 852380-64-4 (3R,5R)-5-[(tert-butyldimethylsilyl)oxy]-1,3-dihydroxy-4-methylene-cyclohexanecarboxylic acid methyl ester 
• 766529-88-8 (1R,3R,5R)-1-acetoxy-3-[(tert-butyldimethylsilyl)oxy]-6-oxa-bicyclo[3.2.1]octane-4,7-dione 
• 1451070-65-7 (3aR,4R,6R,7aR)-4,6-bis[(tert-butyldimethylsilyl)oxy]-5-methylene-3,3a,4,5,6,7-hexahydroindazole-7a-carboxylic acid methyl ester 
• 1227058-14-1 (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-4-methylene-cyclohex-1-enecarboxylic acid methyl ester 
• 213250-59-0 methyl (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-methylenecyclohexanecarboxylate 
• 1428946-46-6 (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-2-methyl-4-methylene-cyclohex-1-enecarbaldehyde 

Downstream Products

• 1428946-58-0 (20S)-1α,25-dihydroxy-2-methylene vitamin D₃ 
• 1428946-59-1 (5E)-(20S)-1α,25-dihydroxy-2-methylene vitamin D₃ 

Relevant academic research and scientific papers

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-METHYLENE ANALOGS OF CALCITRIOL AND RELATED COMPOUNDS

Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D3, (20S)-1α-hydroxy-2-m

Synthesis and Biological Activity of 2-Methylene Analogues of Calcitriol and Related Compounds

In an attempt to prepare Vitamin D analogues that are superagonists, (20R)- and (20S)-isomers of 1α-hydroxy-2-methyleneVitamin D3 and 1α,25-dihydroxy-2-methyleneVitamin D3 have been synthesized. To prepare the desired A-ring dienyne

2-methylene-vitamin D analogs and their uses

This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-1α,25 -dihydroxy-2-methylene-vitamin D3 as well as (5E)-(20S)-1α,25-dihydroxy-2 -methylene-vitamin D3 and (20R)-1α,25-dihydroxy-2-methylene-vitamin D