1451073-40-7Relevant academic research and scientific papers
Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation
Castaneda, Lourdes,Maruani, Antoine,Schumacher, Felix F.,Miranda, Enrique,Chudasama, Vijay,Chester, Kerry A.,Baker, James R.,Smith, Mark E. B.,Caddick, Stephen
supporting information, p. 8187 - 8189 (2013/09/12)
In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody-drug conjugate bearin
LYSOSOME-CLEAVABLE LINKER
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Page/Page column 41, (2013/08/28)
The present invention relates to a linker for forming conjugates of a protein or peptide with a therapeutically active agent and which comprise a thiomaleamic acid moiety that is susceptible to cleavage under the pH conditions prevalent in the lysosome.
