14511-72-9Relevant academic research and scientific papers
Pentacylic triterpenes from Lavandula coronopifolia: structure related inhibitory activity on α-glucosidase
Elsbaey, Marwa,Mwakalukwa, Rogers,Shimizu, Kuniyoshi,Miyamoto, Tomofumi
, p. 1436 - 1444 (2019/08/26)
Ten pentacyclic triterpenes (1-10) were isolated from Lavandula coronopifolia. We evaluated their α-glucosidase inhibitory activity, and found that the aglycones, 1, 2, 3, 4, 7 and 10 showed superior IC50 values to the positive control. In order to explain the structural requirements for α-glucosidase inhibitory activity, eleven derivatives were prepared, including one new compound, 2-formyl-(A)1–19α-hydroxy-1-norursane-2, 12-dien-28-oic acid 10c. The results demonstrated that a free hydroxyl at ring-A and a free carboxylic group at position 28 are key structural features for the α-glucosidase inhibitory activity, also that an ursane skeleton is optimum for the activity. Additionally, enzyme kinetic analysis of pomolic acid 2, the most potent compound, revealed that it inhibited α-glucosidase in a mixed-type manner. The molecular docking simulation validated this type of inhibition and highlighted the role of the C-3 hydroxyl and C-28 carboxylic groups in interaction with the enzyme in silico.
Triterpenoidal glycosides from the seeds of Dendrocalamus strictus
Rai, Renu,Siddiqui,Singh
, p. 518 - 520 (2007/10/03)
Two new triterpenoidal glycosides have been isolated from the seeds of plant Dendrocalamus strictus and are characterised as 3β, 21β, 28- trihydroxyolean-12-en-28-O-{-β-D-arabinopyranosyl(1→3)}-β-D- arabinopyranosyl(1→3)-β-D-arabinopyranoside 1 and 3β, 19α-dihydroxyurs- 12-en-28-oate-3-O-β-D-arabinopyranoside 2 on the basis of chemical and spectral evidence.
TWO TRITERPENOID GLYCOSIDES FROM LEAVES OF ILEX CORNUTA
Nakanishi, Tsutomu,Terai, Hiroko,Nasu, Masao,Miura, Iwao,Yoneda, Kaisuke
, p. 1373 - 1378 (2007/10/02)
Two new triterpene glycosides, a diglycoside (as the corresponding methyl ester) and a bisdesmoside were isolated from leaves of Ilex cornuta.Their structures, termed as ilexside I methyl ester and ilexside II, have been established to be 3β-O-2)-α-L-arabinopyranosyl>-pomolic acid methyl ester and 3β-O-2)-α-L-arabinopyranosyl>-pomolic acid-(28->1)-β-D-glucopyranosyl ester, respectively, based on chemical and spectral evidence, but notably on novel and efficient application of high resolution 1H NMR spectroscopy. - Key Word Index: Ilex cornuta; Aquifoliaceae; two triterpene glycosides; pomolic acid; ilexside I methyl ester; ilexside II.
