1451144-38-9

Upstream product

• 1451144-17-4 3-allyl 9-(tert-butyl) 4-oxo-1,2,3,4-tetrahydro-9H-carbazole-3,9-dicarboxylate 
• 1451144-14-1 tert-butyl 4-oxo-1,2,3,4-tetrahydro-9H-carbazole-9-carboxylate 
• 15128-52-6 1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1451144-27-6 (rac)-3-allyl 9-tert-butyl 3-benzyl-4-oxo-3,4-dihydro-1H-carbazole-3,9(2H)-dicarboxylate 

Relevant academic research and scientific papers

Studies on the enantioselective synthesis of carbazolones as intermediates in aspidosperma and kopsia alkaloid synthesis

Two strategies for the assembly of homochiral carbazolones have been investigated. The first exploited desymmetrisation of 1,3-cyclohexadione derivatives however this failed to deliver satisfactory outcomes. An orthogonal route exploiting palladium catalysed decarboxylative allylation of racemic carbazolone β-ketoesters has been developed. Herein we report full details on the development of this reaction and clarify apparent discrepancies between our preliminary reports and those of Shao.

Enantioselective palladium-catalyzed decarboxylative allylation of carbazolones and indolones: Formal synthesis of (+)-kopsihainanineA

Adding value: A four-step synthesis of enantioenriched carbazolone and indolone derivatives has been developed using an enantioselective Pd-catalyzed decarboxylative allylation. The scope of this reaction is broad, and the materials are suited for natural product synthesis, shown with the completion of a formal synthesis of (+)-kopsihainanine (see scheme). Copyright