145119-69-3

Basic information

• Product Name: rac-5-[(tert-butyldimethylsilyl)oxy]hexan-1-ol
• Synonyms: rac-5-[(tert-butyldimethylsilyl)oxy]hexan-1-ol
• CAS NO: 145119-69-3
• Molecular Weight: 232.439
• Mol File: 145119-69-3.mol

Chemical Properties

• CAS DataBase Reference: rac-5-[(tert-butyldimethylsilyl)oxy]hexan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: rac-5-[(tert-butyldimethylsilyl)oxy]hexan-1-ol(145119-69-3)
• EPA Substance Registry System: rac-5-[(tert-butyldimethylsilyl)oxy]hexan-1-ol(145119-69-3)

Safety Data

• Hazardous Substances Data: 145119-69-3(Hazardous Substances Data)

Upstream product

• 112-47-0 1,10-Decanediol 
• 145119-68-2 rac-1,5-bis[(tert-butyldimethylsilyl)oxy]hexane 

Downstream Products

• 928-40-5 hexane-1,5-diol 

Relevant articles and documents

Cleavage of tert-butyldimethylsilyl ethers by chloride ion

A general method for the selective cleavage of tert-butyldimethylsilyl ethers in the presence of tert-butyldiphenylsilyl ones has been established using a combination of H2O and a concentrated solution of LiCl in DMF at 90°C. Since no acids, bases, reducing or oxidizing agents are used, the method seems to be very appropiate for the deprotection of TBDMS ethers in the presence of other sensitive functional groups.

Selective deprotection of tert-butyldimethylsilyl ether with lithium bromide and 18-crown-6

Lithium bromide, in the presence of a crown ether, has been found to selectively remove primary tert-butyldimethylsilyl ethers under controlled conditions. This selectivity has been utilized to synthesize 3'-TBDMS-2'- deoxyuridine in one step from the diprotected compound.