1451206-82-8

Basic information

• Product Name: C₁₅H₂₀N₂O₄
• Synonyms: C₁₅H₂₀N₂O₄
• CAS NO: 1451206-82-8
• Molecular Weight: 292.335
• Mol File: 1451206-82-8.mol

Chemical Properties

• CAS DataBase Reference: C₁₅H₂₀N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₂₀N₂O₄(1451206-82-8)
• EPA Substance Registry System: C₁₅H₂₀N₂O₄(1451206-82-8)

Safety Data

• Hazardous Substances Data: 1451206-82-8(Hazardous Substances Data)

Upstream product

• 3262-72-4 (R)-N-tert-butoxycarbonyl serine 
• 622-33-3 N-benzyloxyamine 

Relevant articles and documents

In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria

As a complement to the renowned bicyclic β-lactam antibiotics, monocyclic analogues provide a breath of fresh air in the battle against resistant bacteria. In that framework, the present study discloses the in silico design and unprecedented ten-step synthesis of eleven nocardicin-like enantiomerically pure 2-{3-[2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-2-oxoazetidin-1-yl}acetic acids starting from serine as a readily accessible precursor. The capability of this novel class of monocyclic 3-amino-β-lactams to inhibit penicillin-binding proteins (PBPs) of various (resistant) bacteria was assessed, revealing the potential of α-benzylidenecarboxylates as interesting leads in the pursuit of novel PBP inhibitors. No deactivation by representative enzymes belonging to the four β-lactamase classes was observed, while weak inhibition of class C β-lactamase P99 was demonstrated.

LINEAR PEPTIDE ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.