1451218-41-9Relevant academic research and scientific papers
Palladium-catalyzed carbenoid based N-H bond insertions: Application to the synthesis of chiral α-amino esters
Liu, Gang,Li, Jian,Qiu, Lin,Liu, Li,Xu, Guangyang,Ma, Bing,Sun, Jiangtao
, p. 5998 - 6002 (2013/09/12)
A highly efficient palladium-catalyzed carbenoid based N-H bond insertion has been developed. The α-amino esters were obtained in high isolated yields. Moreover, by choosing a suitable chiral auxiliary, stereoselective Pd-catalyzed N-H insertion has been realized. The chiral α-amino esters were obtained in high yields (up to 91%) and with excellent diastereoselectivities (d.r. > 19:1). The Royal Society of Chemistry.
