1451260-45-9Relevant academic research and scientific papers
Total synthesis of marine sesquiterpenoid sinularianin b and 8-epi-sinularianin b
Ota, Koichiro,Miyaoka, Hiroaki
, p. 442 - 461 (2015)
The enantioselective total synthesis of marine sesquiterpenoid sinularianin B, isolated from the Formosan soft coral Sinularia sp., has been accomplished in 16 steps based on a highly concise synthetic strategy. The synthesis features two highly stereoselective sulfone-mediated reactions, including a key tandem intermolecular-intramolecular alkylation developed in our laboratory, and a palladium-catalyzed desulfonylation of an allyl sulfone through ?-allyl palladium complex formation.
First total synthesis of (-)-sinularianin B
Ota, Koichiro,Miyaoka, Hiroaki
, p. 8148 - 8150 (2013/09/12)
The first enantioselective total synthesis of (-)-sinularianin B, a structurally unique sesquiterpenoid isolated from the Formosan soft coral Sinularia sp., has been accomplished in 16 steps with 39.5% overall yield. Key transformations include formation of a cyclopentane possessing a tertiary hydroxy group via a tandem intermolecular-intramolecular alkylation involving a 5-endo cyclization.
