145127-38-4

Usage

Uses

Used in Pharmaceutical Industry:
(3-Morpholinophenyl)methanol is used as an intermediate in the synthesis of various pharmaceuticals for its ability to react with other compounds to form complex organic molecules, contributing to the development of new drugs.
Used in Chemical Industry:
In the chemical industry, (3-Morpholinophenyl)methanol serves as a building block in the manufacturing of various chemicals, playing a crucial role in the creation of organic materials.
Used as a Reagent in Organic Synthesis:
(3-Morpholinophenyl)methanol is utilized as a reagent in organic synthesis, facilitating the formation of desired products in chemical reactions, which is essential for advancing research and development in the field of organic chemistry.

Upstream product

• 446866-87-1 3-morpholin-4-ylbenzaldehyde 
• 110-91-8 morpholine 
• 197172-69-3 N-(3-methoxycarbonylphenyl)morpholine 
• 618-91-7 methyl 3-iodo-benzoate 
• 1498257-18-3 C₁₇H₂₉NO₂Si 
• 103978-12-7 [(3-bromobenzyl)oxy](tert-butyl)dimethylsilane 
• 15852-73-0 (3-Bromophenyl)methanol 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 144801-08-1 4-(3-(chloromethyl)phenyl)morpholine 
• 1314884-52-0 C₁₅H₁₇N₃O₂S₂ 
• 1314884-51-9 4-(3-(bromomethyl)phenyl)morpholine 
• 1314884-55-3 C₂₂H₂₁N₃O₃S₂ 
• 1314884-54-2 C₂₂H₂₁N₃O₄S₂ 
• 1314884-53-1 C₂₂H₂₁N₃O₄S₂ 

Relevant academic research and scientific papers

ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND

The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBN E3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBN E3 ubiquitin ligase.

Combined KOH/BEt3Catalyst for Selective Deaminative Hydroboration of Aromatic Carboxamides for Construction of Luminophores

The selective catalytic C-N bond cleavage of amides into value-added amine products is a desirable but challenging transformation. Molecules containing iminodibenzyl motifs are prevalent in pharmaceutical molecules and functional materials. Here we established a combined KOH/BEt3 catalyst for deaminative hydroboration of acyl-iminodibenzyl derivatives, including nonheterocyclic carboxamides, to the corresponding amines. This novel transition-metal-free methodology was also applied to the construction of Clomipramine and luminophores.

Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates

A palladium-catalyzed decarboxylative benzylation reaction of α,α-difluoroketone enolates is reported, in which the key C(α)?C(sp3) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α-benzyl-α,α-difluoroketone-based products, and should be useful for accessing biological probes.

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

The free fatty acid receptor 1 (FFA1) has gained significant interest as a novel antidiabetic target. Most of FFA1 agonists reported in the literature bearing a common biphenyl scaffold, which was crucial for toxicity verified by the researchers of Daiichi Sankyo. Herein, we describe the systematic exploration of non-biphenyl scaffold and further chemical modification of the optimal pyrrole scaffold. All of these efforts led to the identification of compound 11 as a potent and orally bioavailable FFA1 agonist without the risk of hypoglycemia. Further molecular modeling studies promoted the understanding of ligand-binding pocket and might help to design more promising FFA1 agonists.