145131-46-0 Usage
Chemical class
Urea derivative
Structure
Phenyl group with two isopropyl substitutions
Urea moiety connected through a cyclopentylmethyl linker
Indole group
Dimethylaminoethyl group
Potential applications
Pharmaceuticals
Agrochemicals
Materials science
Biological and chemical properties
Diverse due to complex structure
Research and development
Interesting compound for further study
Check Digit Verification of cas no
The CAS Registry Mumber 145131-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,3 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 145131-46:
(8*1)+(7*4)+(6*5)+(5*1)+(4*3)+(3*1)+(2*4)+(1*6)=100
100 % 10 = 0
So 145131-46-0 is a valid CAS Registry Number.
145131-46-0Relevant articles and documents
New indole derivatives as ACAT inhibitors: Synthesis and structure-activity relationships
Bellemin,Decerprit,Festal
, p. 123 - 132 (2007/10/03)
A series of ureas containing the indole group were synthesized and assessed for their ability to inhibit arterial and intestinal ACAT and to lower plasma total cholesterol in a cholesterol-fed rat model. The structural modulations carried out in this series led to compounds which proved to be very active in both the inhibition of aortic ACAT in vitro and the inhibition of rat cholesterol intestinal absorption in vivo. Several compounds from this series exhibit a remarkable hypocholesterolaemic effect with ED25 less than 0.1 mg/kg po.