1451408-79-9Relevant academic research and scientific papers
Bifunctional building blocks in the Ugi-azide condensation reaction: A general strategy toward exploration of new molecular diversity
Gunawan, Steven,Hulme, Christopher
, p. 6036 - 6046 (2013/09/12)
1,5-Disubstituted tetrazoles are an important drug-like scaffold known for their ability to mimic the cis-amide bond conformation. The scaffold is readily accessible via substitution of the carboxylic acid component of the Ugi multi-component reaction (MCR) with TMSN3 in what is herein denoted the Ugi-azide reaction. This full paper presents a concise, novel, general strategy to access a plethora of new heterocylic scaffolds utilizing tethered aldo/keto-acids/esters in the Ugi-azide reaction followed by a ring closing event that generates novel highly complex bis-heterocyclic lactam-tetrazoles. The Royal Society of Chemistry.
