145142-82-1

Usage

InChI:InChI=1/C34H56NO10P/c1-4-25(3)11-6-9-16-32(37)43-29-15-10-13-26(23-29)12-7-8-14-28(36)24-31(45-46(40,41)42)34(39,21-22-35)20-19-30-27(5-2)17-18-33(38)44-30/h7-8,12,14,17-20,25-31,36,39H,4-6,9-11,13,15-16,21-24,35H2,1-3H3,(H2,40,41,42)/b12-7+,14-8+,20-19+

Upstream product

• 943144-59-0 (2R,3S,4Z)-3-ethyl-2,6-bis(4-methoxybenzyloxy)-4-hexen-1-ol 
• 943144-58-9 C₂₄H₃₀O₅ 
• 943144-57-8 (2R,3S)-3-ethyl-1,2-(4-methoxybenzylidenedioxy)-6-(4-methoxybenzyloxy)-4-hexyne 
• 943144-56-7 (2R,3S)-3-ethyl-6-(4-methoxybenzyloxy)-4-hexyne-1,2-diol 
• 521274-48-6 (1S,3R)-3-{(1Z,3Z,5R,7R,8R,9E)-8-(2-{[(allyloxyl)carbonyl]amino}ethyl)-7-{[bis(allyloxy)phosphoryl]oxy}-10-[(2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-5-hydroxy-8-[(trimethylsilyl)oxy]deca-1,3,9-trienyl}cyclohexyl (6S)-6-methyloctanoate 
• 467234-69-1 6-methyl-octanoic acid 3-[8-(2-allyloxycarbonylamino-ethyl)-7-(bis-allyloxy-phosphoryloxy)-5-chloroacetoxy-10-(3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-trimethylsilanyloxy-deca-1,3,9-trienyl]-cyclohexyl ester 
• 467234-68-0 (S)-6-Methyl-octanoic acid (1S,3R)-3-[(1Z,3Z,9E)-(5R,7R,8R)-8-(2-allyloxycarbonylamino-ethyl)-5-(2-chloro-acetoxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-7-hydroxy-8-trimethylsilanyloxy-deca-1,3,9-trienyl]-cyclohexyl ester 
• 467234-67-9 (S)-6-Methyl-octanoic acid (1S,3R)-3-[(1Z,3Z,9E)-(5R,7R,8R)-8-(2-allyloxycarbonylamino-ethyl)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,7-dihydroxy-8-trimethylsilanyloxy-deca-1,3,9-trienyl]-cyclohexyl ester 
• 467234-65-7 (S)-6-Methyl-octanoic acid (1S,3R)-3-((1Z,3Z)-4-{(4R,6R)-6-[(E)-(R)-1-(2-allyloxycarbonylamino-ethyl)-3-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-1-hydroxy-allyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-buta-1,3-dienyl)-cyclohexyl ester 
• 685530-39-6 [(7Z,9Z)-(3R,4R,6R)-3-[(E)-2-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-3,6-dihydroxy-10-((1R,3S)-3-hydroxy-cyclohexyl)-4-phosphonooxy-deca-7,9-dienyl]-carbamic acid allyl ester 
• 467234-63-5 [(7Z,9Z)-(3R,4R,6R)-3-[(E)-2-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-3,4,6-trihydroxy-10-((1R,3S)-3-hydroxy-cyclohexyl)-deca-7,9-dienyl]-carbamic acid allyl ester 
• 467234-64-6 ((E)-(R)-5-((2S,3S)-3-Ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-hydroxy-3-{(4R,6R)-6-[(1Z,3Z)-4-((1R,3S)-3-hydroxy-cyclohexyl)-buta-1,3-dienyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-pent-4-enyl)-carbamic acid allyl ester 
• 521274-34-0 phenoxy-acetic acid 1-[2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5-[2-(3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-5-(2-trityloxy-ethyl)-[1,3]dioxolan-4-ylmethyl]-5-[3-(4-methoxy-phenoxymethoxy)-cyclohexyl]-penta-2,4-dienyl ester 
• 521274-37-3 6-methyl-octanoic acid 3-[8-(2-allyloxycarbonylamino-ethyl)-7-(bis-allyloxy-phosphoryloxy)-10-(3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5-phenoxyacetoxy-8-trimethylsilanyloxy-deca-1,3,9-trienyl]-cyclohexyl ester 

Downstream Products

• 467234-66-8 (S)-6-Methyl-octanoic acid (1S,3R)-3-[(1Z,3Z,9E)-(5R,7R,8R)-8-(2-allyloxycarbonylamino-ethyl)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,7,8-trihydroxy-deca-1,3,9-trienyl]-cyclohexyl ester 
• 467234-65-7 (S)-6-Methyl-octanoic acid (1S,3R)-3-((1Z,3Z)-4-{(4R,6R)-6-[(E)-(R)-1-(2-allyloxycarbonylamino-ethyl)-3-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-1-hydroxy-allyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-buta-1,3-dienyl)-cyclohexyl ester 
• 504-99-4 (6S)-6-methyloctanoic acid 

Relevant academic research and scientific papers

Total synthesis of leustroducsin B

(Chemical Equation Presented) Leustroducsin B was synthesized via a convergent route based on division of the leustroducsin molecule into three segments A, B, and C. Two coupling reactions (Julia coupling reaction and Nozaki-Hiyama-Kishi (NHK) reaction) w

Total synthesis of leustroducsin B via a convergent route

Total synthesis of leustroducsin B was achieved via a convergent route, which includes Julia coupling reaction of segment A with segment B followed by Stille coupling reaction of segment C.

Total synthesis of leustroducsin B

A convergent total synthesis of leustroducsin B (1), which is known to exhibit a variety of biological activities, was successfully carried out. Notable features of our synthesis include construction of the C8 stereocenter by lipase-mediated desymmetrizat

Chemical transformation of Leustroducsins: Synthesis of Leustroducsin B

Chemical transformation of Leustroducsin H to Leustroducsin B has been successfully accomplished in 11 steps including enzymatic hydrolysis of phosphate ester. The process described here enables to differentiate all hydroxyl groups, amino and phosphate fu