145145-84-2Relevant academic research and scientific papers
Asymmetric [2 + 2] cycloaddition reaction catalyzed by a chiral titanium reagent
Narasaka, Koichi,Hayashi, Yujiro,Shimadzu, Hideshi,Niihata, Shigeo
, p. 8869 - 8885 (2007/10/02)
In the presence of certain Lewis acids, alkenes containing an alkylthio group (for example, ketene dithioacetals, alkenyl sulfides, alkynyl sulfides, and allenyl sulfides) react with electron deficient olefins to give the corresponding cyclobutane, cyclobutene, or methylene cyclobutane derivatives. By employing a chiral titanium catalyst generated in situ from dichlorodiisopropoxytitanium and a tartrate-derived chiral diol, the [2 + 2] cycloaddition reaction proceeds with high enantioselectivity.
