145165-97-5

Upstream product

• 323584-20-9 (1S,2S,5S)-2,6,6-Trimethyl-3-[(Z)-pyridin-2-ylmethylimino]-bicyclo[3.1.1]heptan-2-ol 
• 138175-23-2 (1R,2R,5R)-2,6,6-Trimethyl-3-[(E)-pyridin-2-ylmethylimino]-bicyclo[3.1.1]heptan-2-ol 
• 192223-62-4 (S)-3-Methyl-2-((S)-2-phenyl-1-pyridin-2-yl-ethylamino)-butan-1-ol 
• 138175-31-2 (1S,2S,5S)-2,6,6-Trimethyl-3-[(Z)-2-phenyl-1-pyridin-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol 

Downstream Products

• 173345-78-3 (S)-N-Boc-2-phenyl-1-(2-pyriidyl)ethylamine 

Relevant academic research and scientific papers

Addition of organozincate reagents to imines derived from (S)-1-phenylethylamine and ethyl (S)-valinate-synthesis of (S)-1-(2-pyridyl)alkylamines

Triorganozincates were added to aliphatic aldimines derived from (S)-1-phenylethylamine and (S)-valine esters in the presence of boron trifluoride to give secondary amines with low diastereoselectivies. From mixed zincates, most alkyl groups (methyl, ethy

A new asymmetric synthesis of (S)-dolaphenine and its heteroaromatic congeners utilizing (+)-2-hydroxy-3-pinanone and (-)-3-hydroxy-2-caranone as chiral auxiliaries

(+)-2-hydroxy-3-pinanone ((+)-HyPN,(+)-2a) and (-)-3-hydroxy-2-caranone ((-)-2b) were respectively converted to the corresponding Schiff bases 18a and 18b with 1-(2-thiazolyl)methylamine (17). Alkylation followed by removal of the chiral auxiliaries (+)-2a and (-)-2b afforded (S)-dolaphenine (10) as an optically pure form. The method was applied to the asymmetric synthesis of the dolaphenine analogs 27a-d.

Asymmetric Synthesis XV: Enantioselective Syntheses of (R) or (S)-α-Substituted-(2-pyridyl) Methylamines via Chiral Pinanone Ketimine Template

Enantioselective synthesis of (R) or (S)-α-substituted-(2-pyridyl)-methylamines (5), using 2-hydroxypinan-3-one (1) as chiral auxiliary, had been studied.The e.e. values of 5 were 89-98percent, which determined by chiral capillary GC (stationary phase; Chirasil-Val).