145167-29-9

Upstream product

• 66222-28-4 (benzyloxymethyl)tributylstannane 
• 115509-13-2 (3aR,6aR)-2,2-Dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 
• 67642-42-6 2,3,5,6-di-O-isopropylidene-D-gulono-1,4-lactone 
• 23843-32-5 2,3-Isopropylidene-D-gulono-γ-lactone 
• 89291-75-8 (3aR*,6aR*)-6-Benzyloxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-one 

Downstream Products

• 145167-39-1 (1S,2S,3R,4R)-1-amino-4-benzyloxymethyl-2,3-dimethylmethylenedioxy-1-cyclopentanecarbonitrile 
• 143642-98-2 Dithiocarbonic acid O-[(1S,2S,3R,5R)-5-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylthiocarboxyoxy-cyclopentyl] ester S-methyl ester 
• 143643-08-7 Benzoic acid (1S,2S)-4-(2-amino-6-benzyloxy-purin-9-yl)-2-benzyloxymethyl-cyclopentylmethyl ester 
• 143643-06-5 Benzoic acid (1S,2S)-2-benzyloxymethyl-4-(6-chloro-purin-9-yl)-cyclopentylmethyl ester 
• 143642-96-0 ((3aS,4R,6R,6aS)-6-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yloxy)-tert-butyl-diphenyl-silane 
• 143643-10-1 Benzoic acid (1R,2R,4R)-2-benzyloxymethyl-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentylmethyl ester 
• 143643-09-8 Benzoic acid (1R,2R,4R)-4-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-benzyloxymethyl-cyclopentylmethyl ester 
• 143642-97-1 (1S,2S,3R,5R)-3-Benzyloxymethyl-5-(tert-butyl-diphenyl-silanyloxy)-cyclopentane-1,2-diol 
• 143642-99-3 ((1S,4R)-4-Benzyloxymethyl-cyclopent-2-enyloxy)-tert-butyl-diphenyl-silane 
• 143643-05-4 Benzoic acid (1S,2S)-2-benzyloxymethyl-4-methanesulfonyloxy-cyclopentylmethyl ester 
• 143643-03-2 Benzoic acid (1R,2R)-2-benzyloxymethyl-4-oxo-cyclopentylmethyl ester 
• 143643-07-6 Benzoic acid (1R,2R)-4-amino-2-benzyloxymethyl-cyclopentylmethyl ester 
• 143643-04-3 Benzoic acid (1R,2R)-2-benzyloxymethyl-4-hydroxy-cyclopentylmethyl ester 
• 143643-02-1 (3R,4R)-3-Benzyloxymethyl-4-hydroxymethyl-cyclopentanone 

Relevant academic research and scientific papers

SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)

The disclosure is directed to compounds of Formula I, Formula II, and Formula III. Methods of their use and preparation are also described.

Synthesis of an optically active carbocyclic derivative of (+)-hydantocidin

Synthesis of an optically active carbocyclic analogue of (+)-hydantocidin is reported. The spirohydantoin ring formation of cyclopentanone 9, derived from D-gulono-1,4-lactone 3 in 6 steps, was accomplished through α-aminonitrile 10, followed by treatment with chlorosulfonyl isocyanate, to give spirohydantoin 13, which was deprotected with 10% Pd/C, to afford an optically active carbocyclic analogue (+)-2.

Carbocyclic ring-enlarged oxetanocin analogues

Carbocyclic versions of 2′,3′-dideoxy-3′C-hydroxymethyl nucleosides with adenine, guanine, uracil and cytosine bases were synthesized from a common cyclopentenone precursor. The extra hydroxymethyl moiety was introduced by photochemical addition of methan