145167-40-4

Upstream product

• 115509-13-2 (3aR,6aR)-2,2-Dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 145167-39-1 (1S,2S,3R,4R)-1-amino-4-benzyloxymethyl-2,3-dimethylmethylenedioxy-1-cyclopentanecarbonitrile 

Relevant academic research and scientific papers

Synthesis of an optically active carbocyclic derivative of (+)-hydantocidin

Synthesis of an optically active carbocyclic analogue of (+)-hydantocidin is reported. The spirohydantoin ring formation of cyclopentanone 9, derived from D-gulono-1,4-lactone 3 in 6 steps, was accomplished through α-aminonitrile 10, followed by treatment with chlorosulfonyl isocyanate, to give spirohydantoin 13, which was deprotected with 10% Pd/C, to afford an optically active carbocyclic analogue (+)-2.