14517-44-3

Basic information

• Product Name: H-MET-GLU-OH
• Synonyms: L-METHIONYL-L-GLUTAMIC ACID;L-MET-GLU;H-MET-GLU-OH;met-glu;L-Met-L-Glu-OH;Met-Glu-OH;N-L-Methionyl-L-glutamic acid
• CAS NO: 14517-44-3
• Molecular Formula: C₁₀H₁₈N₂O₅S
• Molecular Weight: 278.33
• Mol File: 14517-44-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 205-206 °C
• Boiling Point: 583.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.343±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: H-MET-GLU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-MET-GLU-OH(14517-44-3)
• EPA Substance Registry System: H-MET-GLU-OH(14517-44-3)

Safety Data

• Hazardous Substances Data: 14517-44-3(Hazardous Substances Data)

Usage

General Description

H-MET-GLU-OH, also known as N-methyl-L-glutamic acid, is a synthetic peptide derivative. It consists of N-methylated L-glutamic acid, an amino acid that plays a crucial role in protein synthesis and neurotransmission. The N-methylation of the glutamic acid moiety in H-MET-GLU-OH has been found to enhance the stability and conformational properties of the peptide, making it a useful tool in the study of protein structure and function. Additionally, H-MET-GLU-OH and its derivatives have shown potential therapeutic applications in the treatment of central nervous system disorders and neurodegenerative diseases.

Upstream product

• 80714-61-0 H-Met-Glu-His-Phe-Pro-Gly-Pro 
• 115944-77-9 N-(N-benzyloxycarbonyl-L-methionyl)-L-glutamic acid diethyl ester 
• 1152-62-1 Cbz-Met-OH 
• 63-68-3 L-methionine 
• 98398-16-4 (2S)-2-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-(methylsulfanyl)butanoyl]amino}pentanedioic acid 

Downstream Products

• 116913-09-8 N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid 
• 114795-73-2 N-[N-(N-benzyloxycarbonyl-L-seryl)-L-methionyl]-L-glutamic acid 

Relevant articles and documents

Studies of the aminopeptidase proteolysis of semax analogues with different N-terminal amino acid residues

Proteolysis of semax (Met-Glu-His-Phe-Pro-Gly-Pro, Sem) and its analogues with the substitution of Ala, Gly, Thr, or Trp for the N-terminal Met was studied. This substitution was shown to change the degradation rate of these peptides by leucine aminopeptidase (EC 3.4.11.2, Sigma, Type VI, 9.2 activity units/mg). [Ala1]Sem, [Gly1]Sem, and [Thr1]Sem (the semax analogues) proved to be more stable to the proteolysis than semax itself. It was demonstrated that the primary product of the proteolysis was His-Phe-Pro-Gly-Pro (Sem-5). In the case of [Trp1]Sem, the comparable amount of Glu-His-Phe-Pro-Gly-Pro (Sem-6) was found to be formed along with Sem-5. In was established that all the studied semax analogues could be used as inhibitors of its proteolysis. Pleiades Publishing, Ltd., 2011.