1451750-74-5Relevant articles and documents
Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function
Liu, Xinjun,Wang, Yang,Laurini, Erik,Posocco, Paola,Chen, Han,Ziarelli, Fabio,Janicki, Annick,Qu, Fanqi,Fermeglia, Maurizio,Pricl, Sabrina,Zhang, Cheng-Cai,Peng, Ling
, p. 4662 - 4665 (2013)
A 2-oxoglutaric acid (2-OG) probe bearing a methylene group introduced at the C4 position and a vinyl group to replace the carbonyl group at the C2 position elicited characteristic affinity for NtcA, the 2-OG receptor, while maintaining the signaling function of the parent natural metabolite 2-OG. This discovery opens new perspectives in the design, synthesis, and implementation of specific 2-OG analogues as molecular probes for investigating the complex 2-OG signaling pathways.
