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2α-Hydroxy-5α-cholestan-3-one, also known as 2α-hydroxycholesterol, is a naturally occurring steroid compound derived from cholesterol. It is characterized by the presence of a hydroxyl group at the 2α position and a ketone group at the 3 position of the cholestane ring structure. 2α-Hydroxy-5α-cholestan-3-one plays a significant role in various biological processes, including the regulation of cholesterol metabolism and the synthesis of bile acids. In the human body, 2α-hydroxycholesterol is produced as a metabolite of cholesterol and is involved in the elimination of excess cholesterol through the bile. It has also been implicated in the development of certain diseases, such as atherosclerosis, due to its potential to promote the formation of foam cells in the arterial wall. Research on 2α-hydroxycholesterol continues to explore its role in health and disease, as well as its potential as a biomarker for various conditions.

1452-35-3

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1452-35-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1452-35-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,5 and 2 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1452-35:
(6*1)+(5*4)+(4*5)+(3*2)+(2*3)+(1*5)=63
63 % 10 = 3
So 1452-35-3 is a valid CAS Registry Number.

1452-35-3Relevant academic research and scientific papers

The oxidation of Δ2, Δ2,4 and Δ4,6 steroids with RuO4

Musumeci, Domenica,Roviello, Giovanni N.,Sica, Donato

, p. 173 - 179 (2007/10/03)

In order to find new ways for the functionalization of the A and B rings of the steroid nucleus, the reaction of 5α-androst-2-en-17β-ol 17-acetate (1), cholesta-2,4-diene (4) and cholesta-4,6-dien-3β-ol 3-acetate (7) was examined using stoichiometric amounts of ruthenium tetraoxide to yield 1,2-cis diols and/or α-hydroxy ketones. The reaction of 5α-cholest-2-en-3-ol 3-acetate (9) with ruthenium tetraoxide was also carried out and afforded, apart from an α-hydroxy ketone, also a diketone and a seco-dicarboxylic acid. The structures of all new steroids, including stereochemical details, were deduced by analysis of spectral data.

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