1452006-62-0

Basic information

• Product Name: 4-((4-(mesitylamino)-6-(3-morpholinopropoxy) pyrimidin-2-yl)amino)benzonitrile
• Synonyms: 4-((4-(mesitylamino)-6-(3-morpholinopropoxy) pyrimidin-2-yl)amino)benzonitrile
• CAS NO: 1452006-62-0
• Molecular Weight: 472.59
• Mol File: 1452006-62-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((4-(mesitylamino)-6-(3-morpholinopropoxy) pyrimidin-2-yl)amino)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-(mesitylamino)-6-(3-morpholinopropoxy) pyrimidin-2-yl)amino)benzonitrile(1452006-62-0)
• EPA Substance Registry System: 4-((4-(mesitylamino)-6-(3-morpholinopropoxy) pyrimidin-2-yl)amino)benzonitrile(1452006-62-0)

Safety Data

• Hazardous Substances Data: 1452006-62-0(Hazardous Substances Data)

Upstream product

• 329187-59-9 4-(4,6-dichloropyrimidine-2-yl-amino)benzonitrile 
• 4441-30-9 3-morpholin-4-ylpropan-1-ol 
• 1452007-28-1 4-(4-chloro-6-(mesitylamino)pyrimidin-2-ylamino)benzonitrile 
• 873-74-5 4-Aminobenzonitrile 

Relevant articles and documents

Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility

Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity. The solubility enhancements come from strategic placement of a morpholinylalkoxy substituent in the entrance channel of the NNRTI binding site. Compound 4d shows low-nanomolar activity similar to etravirine towards wild-type HIV-1 and key viral variants.