1452006-74-4

Upstream product

• 4441-30-9 3-morpholin-4-ylpropan-1-ol 
• 1458666-40-4 (E)-4-((4-chloro-6-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)-1,3,5-triazin-2-yl)amino)benzonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 116133-09-6 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzonitrile 

Relevant academic research and scientific papers

Novel Compositions and Methods of Treating HIV-1 Infections Using Same

The present invention includes novel compositions useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of preventing or treating an HIV-1 infection in a subject in need th

Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility

Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity. The solubility enhancements come from strategic placement of a morpholinylalkoxy substituent in the entrance channel of the NNRTI binding site. Compound 4d shows low-nanomolar activity similar to etravirine towards wild-type HIV-1 and key viral variants.