145209-43-4

Basic information

• Product Name: N¹-benzylnorphenserine
• Synonyms: N¹-benzylnorphenserine
• CAS NO: 145209-43-4
• Molecular Weight: 413.519
• Mol File: 145209-43-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N¹-benzylnorphenserine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-benzylnorphenserine(145209-43-4)
• EPA Substance Registry System: N¹-benzylnorphenserine(145209-43-4)

Safety Data

• Hazardous Substances Data: 145209-43-4(Hazardous Substances Data)

Upstream product

• 57-47-6 Physostigmin 
• 100-46-9 benzylamine 
• 116103-15-2 (-)-(3aS)-1-benzyl-3a,8-dimethyl-1,2,3,3a,8,8a-hexahydro-5-methoxypyrrolo[2,3-b]indole 
• 103-71-9 phenyl isocyanate 

Relevant articles and documents

Racemic N1-norphenserine and its enantiomers: Unpredicted inhibition of human acetyl- and butyrylcholinesterase and β-amyloid precursor protein in vitro

The optically pure enantiomers of N1-norphenserine (15, 16) were synthesized and its racemate 17 was prepared by mixing equal parts of each enantiomer. (-)-N1-Norphenserine (15) was prepared by partial synthesis initiated from the natural product, (-)-physostigmine (1). (+)-N 1-Norphenserine (16) was prepared by total synthesis using the Julian oxindole route, with modifications. The in vitro inhibitory activities of 15-17 were quantified against human erythrocyte AChE and plasma BChE as well as against human neuroblastoma cell β-amyloid precursor protein secretion in cell culture. All were active. Racemic compound (17) with a high AChE and β-amyloid precursor protein inhibitory action may warrant further assessment in Alzheimer's disease models.