1452120-07-8

Basic information

• Product Name: (1Z,4E)-1-(4-methoxyphenylamino)-1-(methylthio)-5-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)penta-1, 4-dien-3-one
• Synonyms: (1Z,4E)-1-(4-methoxyphenylamino)-1-(methylthio)-5-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)penta-1, 4-dien-3-one
• CAS NO: 1452120-07-8
• Molecular Weight: 425.549
• Mol File: 1452120-07-8.mol

Chemical Properties

• CAS DataBase Reference: (1Z,4E)-1-(4-methoxyphenylamino)-1-(methylthio)-5-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)penta-1, 4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1Z,4E)-1-(4-methoxyphenylamino)-1-(methylthio)-5-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)penta-1, 4-dien-3-one(1452120-07-8)
• EPA Substance Registry System: (1Z,4E)-1-(4-methoxyphenylamino)-1-(methylthio)-5-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)penta-1, 4-dien-3-one(1452120-07-8)

Safety Data

• Hazardous Substances Data: 1452120-07-8(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1452120-15-8 (E)-N₄-(4-methoxyphenyl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)pyrimidine-2,4-diamine 

Relevant articles and documents

Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents

A series of substituted aryl pyrimidine derivatives was synthesized and evaluated in vitro for their antileishmanial potential against intracellular amastigotes of Leishmania donovani using reporter gene luciferase assay. Among all, 8 compounds showed promising IC50 values ranging from 0.5 to 12.9 μM. Selectivity indices (S.I.) of all these compounds are far better than reference drugs, sodium stibogluconate (SSG) and miltefosine. On the basis of good S.I., compounds were further screened for their in vivo antileishmanial activity against L. donovani/hamster model. Compounds 2d, 4a and 4b have shown significant inhibition of parasitic multiplication that is 88.4%, 78.1% and 78.2%, respectively at a daily dose of 50 mg/kg × 5 days, when administered intraperitoneally. Compound 2d is most promising one, which may provide a new lead that could be exploited as a new antileishmanial agent.