1452154-58-3Relevant academic research and scientific papers
Metal-Free, Visible-Light-Promoted Synthesis of 3-Phosphorylated Coumarins via Radical C?P/C?C Bond Formation
Liu, Dan,Chen, Jian-Qiang,Wang, Xing-Zhi,Xu, Peng-Fei
, p. 2773 - 2777 (2017)
A metal-free, visible-light-promoted direct difunctionalization of alkynoates was achieved under mild conditions. By employing catalytic quantities of the commercially available Eosin Y (EY) as the photocatalyst and tert-butyl-hydroperoxide (TBHP) as the oxidant, we developed a radical tandem phosphorylation/cyclization reaction to synthesize various 3-phosphorylated coumarins with high functional group tolerance, moderate to good yields, and excellent regioselectivities. (Figure presented.).
Silver-catalyzed synthesis of 3-phosphorated coumarins via radical cyclization of alkynoates and dialkyl H -phosphonates
Mi, Xia,Wang, Chenyang,Huang, Mengmeng,Zhang, Jianye,Wu, Yusheng,Wu, Yangjie
supporting information, p. 3356 - 3359 (2014/07/08)
Ag2CO3-catalyzed difunctionalization of alkynes via a radical phosphonation and C-H functionalization tandem process was developed to synthesize various 3-phosphonated coumarins in moderate to high yields with high regioselectivity. A catalytic amount of cheap and nontoxic silver salt was employed in the domino C-P and C-C formation of alkynoates for the first time. Mechanistic studies indicate that the reaction pathway might proceed via the generation and cyclization of a phosphonated vinyl radical intermediate.
