1452160-07-4Relevant academic research and scientific papers
Efficient access to trifluoromethyl diarylpyrrolines and their n-oxides through enantioselective conjugate addition of nitromethane to β,β-disubstituted enones
Kawai, Hiroyuki,Yuan, Zhe,Kitayama, Takashi,Tokunaga, Etsuko,Shibata, Norio
supporting information, p. 5575 - 5579 (2013/06/27)
The cupreidinium salt 1 catalyzes the highly enantioselective conjugate addition of nitromethane to β-aryl-β-trifluoromethyl aryl enones (2). The biologically important chiral pyrrolines 4 and N-oxide 5, having a trifluoromethylated all-carbon quaternary chiral center, were easily synthesized from the key intermediate (R)-3 in high to excellent yields. M.S.=molecular sieves. Copyright
