145219-22-3Relevant academic research and scientific papers
Palladium(0)-catalyzed intramolecular decarboxylative allylation of ortho nitrobenzoic esters
Hossian, Asik,Singha, Shantanu,Jana, Ranjan
supporting information, p. 3934 - 3937 (2014/08/18)
A Pd/Ag bimetallic system has been developed for the decarboxylative allylation of ortho-nitrobenzoic esters in an intramolecular fashion. In contrast to the typical sp2-sp3 cross-coupling approach which requires air and moisture sensitive preformed organometallic reagents, we provide an alternative route to the synthesis of ortho-allyl nitroarenes from the corresponding ortho-nitrobenzoic acid derivatives. The reaction proceeds through a mechanistically distinct decarboxylative metalation pathway. A cooperative reactivity of palladium and silver is crucial for the reaction outcome.
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors
Moretto,Kirincich,Xu,Smith,Wan,Wilson,Follows,Binnun,Joseph-McCarthy,Foreman,Erbe,Zhang,Tam,Tam,Lee
, p. 2162 - 2177 (2007/10/03)
A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallo
PTP1b inhibitors
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Page/Page column 35, (2010/11/08)
This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1B (PTP1B).
Carbapenem antibiotic compounds
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, (2008/06/13)
A carbapenem compound of the formula (I) STR1 wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 is hydroxy or carboxy; and the phenyl ring is optionally further substituted by one or two substituents selected from halo, cyano, C1-4 alkyl, nitro, hydroxy, carboxy, C1-4 alkoxy, trifluoromethyl, C1-4 alkoxycarbonyl, carbamoyl, C1-4 alkylcarbamoyl, di-C1-4 alkylcarbamoyl, amino, C1-4 alkylamino, di-C1-4 alkylamino sulphonic acid, C1-4 alkylS(O)n --(wherein n is 0-2), N-C1-4 alkanesulphonamido, C1-4 alkanoylamino and C1-4 alkanoyl(N-C1-4 alkyl)amino: provided that the phenyl ring is substituted by at least one carboxy; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof.
